Abstract #5073

Neurofluid and Microstructural Evaluation by Time-Dependent Diffusion Analysis and White Matter Parameters in Obstructive Sleep Apnea

Toshiaki Taoka^1,2, Kunihiro Iwamoto³, Seiko Miyata³, Rintaro Ito^1,2, Rei Nakamichi², Toshiki Nakane², Hiroshige Fujishiro³, Kazushige Ichikawa⁴, Akifumi Kamiunten⁵, Nobuyasu Ichinose⁶, Masashi Ikeda³, and Shinji Naganawa²

¹Department of Innovative Biomedical Visualization (iBMV), Nagoya University, Nagoya, Japan, ²Department of Radiology, Nagoya University, Nagoya, Japan, ³Department of Psychiatry, Nagoya University, Nagoya, Japan, ⁴Department of Radiological Technology, Nagoya University, Nagoya, Japan, ⁵Canon Medical Systems Corporation, Otawara, Japan, ⁶CT-MR Solution Planning, Canon Medical Systems Corporation, Otawara, Japan

Synopsis

Keywords: Neurofluids, Neurofluids

Motivation: Evaluating neurofluid dynamics, crucial for brain clearance, requires a comprehensive approach utilizing multiple assessment methods. We explore the role of time-dependent diffusion imaging in this context.

Goal(s): This study examines obstructive sleep apnea, potentially impacting neurofluid dynamics, to assess correlations between time-dependent diffusion parameters and markers of sleep and respiration.

Approach: In 42 patients, we analyzed correlations between polysomnography-derived indicators and ΔADC (ADC_OGSE- ADC_PGSE) in deep white matter.

Results: ΔADC correlated well with respiratory parameters, while correlations with sleep markers were limited.

Impact: ΔADC could serve as an indicator of brain microstructural changes linked to respiratory function, with implications for evaluating neurofluid dynamics.

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