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Abstract #5081

MRS Insights into Cerebellar Alterations and Motor Variations in Welders Exposed to Manganese

Jessica Ann George1, Brian Bozymski1, Gianna Nossa1, Cora Mizimakoski1, Chang Geun Lee1, Jae Hong Park1, Roslyn Harold2, Dan Foti2, and Ulrike Dydak1,3,4
1School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2Department of Psychological Sciences, Purdue University, West Lafayette, IN, United States, 3Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 4Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

Synopsis

Keywords: Other Neurodegeneration, Parkinson's Disease, Toxicity, Cerebellum, Neurodegeneration, MRS

Motivation: Occupational Manganese (Mn) exposure is linked to neurotoxicity, yet its impact on cerebellar motor control and metabolism remains unexplored.

Goal(s): In this study, we aim to determine if Mn cumulative exposure levels can be predictive of neurotoxicity identified through changes in GABA, GSH, and/or Glu concentrations and motor functions.

Approach: Participants underwent MRS and Neuropsychological testing. Correlations between metabolites, Mn exposure and Motor functions were examined.

Results: Mn exposure was associated with increased motor scores (rigidity, tremor) and metabolite changes, notably elevated Glx and reduced GSH, indicating oxidative stress and excitatory imbalance.

Impact: This study examines the cerebellum’s response to Mn overexposure, linking elevated Mn to disrupted glutamatergic signaling and potential oxidative stress. Findings could support stricter occupational health guidelines and further research on Mn’s effects on motor control and neurodegenerative risks.

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