Keywords: Neuroinflammation, COVID-19
Motivation: Post-COVID fatigue likely involves the cingulate cortex via neuroinflammatory mechanisms, but the impact of COVID-19 on CC volume through inflammation is still unknown.
Goal(s): Therefore, this study investigated the relationship between immune biomarkers and the subregion of CC, neuropsychiatric symptoms in early post-COVID-19 patients.
Approach: The subregions of CC were measured using Freesurfer, then analyzed the association between CC subregions, peripheral CRP and neuropsychiatric assessments.
Results: In post-COVID-19 fatigue patients, the anterior CC (ACC) volume increased in high CRP cases compared to low CRP group. Additionally, higher CRP level and larger ACC volume were associated with more severe fatigue symptoms.
Impact: This study provides direct evidence of an association between immune biomarkers, ACC, and fatigue symptoms. These results point towards a putative etiological model of post-COVID-19 fatigue, in which elevated peripheral proteins are associated with structural changes in the ACC.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords