Keywords: Neuroinflammation, Neuroinflammation
Motivation: This study investigates brain atrophy patterns associated with gait and cognitive abnormalities in HIV-infected individuals.
Goal(s): Motivated by the need to understand the neurological impact of HIV, the goals were to identify specific atrophy patterns and elucidate pathological mechanisms.
Approach: A multi-center approach involved MRI, gait assessments, and cognitive evaluations, with clustering and virtual histology for analysis.
Results: The results revealed two distinct atrophy subgroups, highlighting differences in gait and cognitive impairments, with gene expression analyses indicating significant roles for oligodendrocytes and interneurons, offering insights into targeted treatment strategies.
Impact: This study provides insights into how infectious and systemic diseases, such as HIV, affect the brain by integrating multimodal data including imaging, behavioral assessments, and gene transcription analysis. This comprehensive approach enables a deeper understanding of disease pathology and mechanisms.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords