Keywords: Gray Matter, Functional Connectivity
Motivation: Previous studies have reported alterations in brain structure and function associated with hypothyroidism. Whether there are alterations in the hypothalamus subunits is unknown.
Goal(s): Our goal was to explore changes in the hypothalamus subunits of hypothyroidism using magnetic resonance imaging (MRI) technology.
Approach: We assessed the intergroup differences of volumes and seed-based functional connectivity (FC) in hypothalamus subunits, as well as thyroid function indicators and neuropsychological scores. Moreover, a correlation analysis was performed to explore relationships between these factors.
Results: The volume and seed-based FC of hypothalamus subunits changed in hypothyroidism patients. Furthermore, there was correlation between the volume and thyroid function indicators.
Impact: This work may find alterations in the hypothalamus subunits at different phases of hypothyroidism, which may help us better understood the mechanisms underlying the brain damage caused by hypothyroidism.
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