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Abstract #5095

Early GBM recurrence: the influence of peri-lesional oedema and the disconnectome

Manaal Tariq1, James Ruffle1, Samia Mohinta1, Sebastian Brandner1, Parashkev Nachev1, and Harpreet Hyare1
1UCL, London, United Kingdom

Synopsis

Keywords: Diagnosis/Prediction, Machine Learning/Artificial Intelligence

Motivation: Recent evidence suggests that, in glioblastoma, an ‘immune cold’ margin may lie within areas of oedema, influencing treatment resistance and early tumour recurrence.

Goal(s): To identify features of the perilesional oedema associated with early tumour recurrence and the corresponding anatomical localization.

Approach: In the largest investigation of glioma patients (n=4908), we investigate the influence of the disconnectome, which describes the estimate of disconnections which occur when lesions interrupt normal water matter connectivity, on glioblastoma recurrence.

Results: We identify radiomic features of perilesional oedema and disconnectome, that influence time to early tumour recurrence; recurrence less than 6 months from completion of radical radiotherapy.

Impact: Identification of features in the peri-lesional oedema and disconnectome associated with early tumour recurrence will enable precision treatment planning and personalised imaging surveillance in glioblastomas.

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