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Abstract #5160

LUMBER: a Custom 3D Printed Mold Platform for Ex Vivo Sampling of Viable, Clinically Significant Prostate Cancer

Chris Du1, Nicholas Lanzotti1, Goran Rac2, Jeffrey Ellis3, Victor Chen1, Maria M Picken4, Guliz A Barkan4, Gopal N Gupta1,5, and Steven M Shea6
1Urology, Loyola University Chicago, Maywood, IL, United States, 2Urology, Lexington Medical Center, West Columbia, SC, United States, 3Urology, VA Boston Healthcare System, Boston, MA, United States, 4Pathology, Loyola University Chicago, Maywood, IL, United States, 5Surgery, Loyola University Chicago, Maywood, IL, United States, 6Radiology and Medical Imaging, Loyola University Chicago, Maywood, IL, United States

Synopsis

Keywords: Prostate, Prostate, 3D Print, tissue harvest, pathology, biopsy

Motivation: Currently, no reliable way exists to sample fresh, viable prostate cancer tissue in a clinically localized setting. This hampers basic science research on prostate cancer cell lines.

Goal(s): Creation of a 3D mold with needle guides from existing prostate boundary & lesion segmentations to enable harvesting cancer tissue from an explanted prostate without impacting the clinical pathology workflow.

Approach: A 3D mold with needle guides was created in Solidworks and then 3D printed. This was used to guide extraction of live cancer tissue via a standard biopsy gun.

Results: In 10/10 patients, biopsies performed with the 3D-printed mold yielded prostate tissue with cancer.

Impact: Our 3D mold platform enables harvesting live cancer from a prostate that has biopsy-proven, positive MR-targeted lesions and resulted in excellent cancer yield across 10 patients. The design is intuitive for clinicians and does not interfere with clinical pathology workflow.

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