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Abstract #5164

Age-modulated Alterations of Prostatic Morphology predicts Lower Urinary Tract Symptoms

Lingtao Zhang1, Wenfeng Mai1, Dong Zhang1, Weiyin Vivian Liu2, and Changzheng Shi1
1the First Affiliated Hospital of Jinan University, Guangzhou, China, 2GE Healthcare, MR Research China, Beijing, China

Synopsis

Keywords: Prostate, Prostate

Motivation: Identifying lower urinary tract symptooms (LUTS) in benign prostatic hyperplasia (BPH) is critical for improving patient management, particular early intervention.

Goal(s): This study aims to explore MRI-based morphological indices for predicting LUTS in BPH patients, especially the age effect.

Approach: Measurements including intravesical protrusion (IPP), membranous urethra-prostate angle (aMUP), and prostatic urethral angle (PUA) were analyzed for between-group difference.

Results: IPP strongly predicted LUST in either two age gropus or obstructive/non-obstructive groups. Additinoally, age-related morphological changes, aMUP and MUL, may increase urethral resistance and energy loss, which were identified as predictive factors, supporting MRI use for early BPH diagnosis.

Impact: This study highlights the clinical importance of MRI-derived morphological indexes, intravesical prostatic protrusion (IPP), for predicting LUTS in BPH patients at the age above 50, facilitating early diagnosis and personalized treatment planning.

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Keywords