Keywords: Digestive, Diagnosis/Prediction
Motivation: Fat malabsorption occurs in several gastrointestinal diseases including celiac disease and cystic fibrosis. Fat malabsorption is diagnosed with stool collection: disliked by patients, and laboratories. Less invasive diagnostics could assess fat malabsorption and be carried out alongside other assessments, improving patient experience, management and burden.
Goal(s): Can non-invasive MRI and MRS techniques quantify unabsorbed fat in the colon?
Approach: Acute high-fat diet with lipase inhibitor model of fat malabsorption in healthy volunteers. MRI, and novel application of MRS, in the colon to detect colonic fat.
Results: MRI with thresholding quantified malabsorbed colonic fat. MRS confirmed fat presence.
Impact: If MRI and MRS could identify and measure fat malabsorption as an alternative diagnostic technique, patients would no longer need to take poorly tolerated diagnostic techniques, this would provide pan-colonic assessment and reduce patient burden.
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