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Abstract #5169

Development of a new imaging test for fat malabsorption

Arantxa Recto1, Abi Spicer2, Darren Sills1, Alaa Alhasani1, Luca Marciani1,3, Caroline Hoad2,3, Penny Gowland2, and Robin Spiller1,3
1Nottingham Digestive Diseases Centre (NDDC), Translational Medicine Sciences, University of Nottingham and NIHR, University of Nottingham, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, University of Nottingham, Nottingham, United Kingdom, 3National Institute for Health and Care Research Biomedical Research Centre (NIHR BRC), University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Digestive, Diagnosis/Prediction

Motivation: Fat malabsorption occurs in several gastrointestinal diseases including celiac disease and cystic fibrosis. Fat malabsorption is diagnosed with stool collection: disliked by patients, and laboratories. Less invasive diagnostics could assess fat malabsorption and be carried out alongside other assessments, improving patient experience, management and burden.

Goal(s): Can non-invasive MRI and MRS techniques quantify unabsorbed fat in the colon?

Approach: Acute high-fat diet with lipase inhibitor model of fat malabsorption in healthy volunteers. MRI, and novel application of MRS, in the colon to detect colonic fat.

Results: MRI with thresholding quantified malabsorbed colonic fat. MRS confirmed fat presence.

Impact: If MRI and MRS could identify and measure fat malabsorption as an alternative diagnostic technique, patients would no longer need to take poorly tolerated diagnostic techniques, this would provide pan-colonic assessment and reduce patient burden.

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