Abstract #5192

Pain chronicity, severity, and widespreadness are related to increased rsfMRI-based Brain Entropy in the Prefrontal cortex

Gianpaolo Del Mauro¹, Yiran Li¹, Jiaao Yu², Peter Kochunov³, Landrew Samuel Sevel⁴, Jeff Boissoneault⁴, Shuo Chen⁵, and Ze Wang¹

¹Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ²University of Maryland College Park, Baltimore, MD, United States, ³University of Texas Health Science Center at Houston, Houston, TX, United States, ⁴University of Minnesota, Minneapolis, MN, United States, ⁵University of Maryland School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: fMRI Analysis, fMRI Analysis, Chronic Pain

Motivation: Chronic pain (CP) represents a severe public health issue and a high socioeconomic burden. The complex nature of CP has made the identification of neuroimaging-based biomarkers extremely challenging

Goal(s): Investigating different dimensions of CP by using brain entropy (BEN) to characterize the randomness and irregularity of brain activity

Approach: Using resting-state fMRI data to estimate BEN for over 10,000 participants, and test the association between BEN and pain chronicity, severity, widespreadness, and duration

Results: Pain chronicity, severity and widespreadness are correlated to increased BEN in the bilateral prefrontal cortex. No association between BEN and pain duration was observed

Impact: Brain Entropy, as a measure of the randomness and irregularity of brain activity, may represent a neuroimaging-based biomarker for chronic pain. Brain Entropy is modifiable through non-invasive brain stimulation, aiding its potential translational value in the treatment of chronic pain

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.