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Abstract #5194

Repeatability and reliability of cerebrovascular reactivity in young adults using multi-echo, multi-contrast MRI

Elizabeth G. Keeling1,2, Maurizio Bergamino1, Lauren R. Ott1, Molly M. McElvogue1, and Ashley M. Stokes1
1Barrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States, 2School of Life Sciences, Arizona State University, Tempe, AZ, United States

Synopsis

Keywords: Task/Intervention Based fMRI, Vascular, Cerebrovascular Reactivity, Multi-Echo, Spin-Echo, Gradient-Echo, Brain, Biomarker

Motivation: Cerebrovascular reactivity (CVR) shows promise as an imaging biomarker of early changes in vascular integrity but is challenging to acquire in non-compliant patient populations. Microvascular-weighted images may be more specific to disease-related pathology, but these acquisitions suffer from lower contrast-to-noise ratio.

Goal(s): We aim to evaluate the repeatability and reliability of CVR mapping using a combined spin- and gradient-echo (SAGE) acquisition across three CVR paradigms requiring varying levels of compliance.

Approach: SAGE-CVR data were collected. Repeatability and reliability metrics were calculated for total and microvascular-weighted SAGE-CVR, with comparison to single-echo CVR.

Results: Repeatability and reliability significantly improved with SAGE-CVR compared to single-echo CVR.

Impact: SAGE-fMRI improves repeatability and reliability of CVR, increasing feasibility of CVR evaluation in patient populations. SAGE-fMRI offers complementary CVR assessments on total and microvascular scales, where a robust microvascular-weighted analysis may be relevant to the study of many neurovascular diseases.

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Keywords