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Abstract #5198

The mouse cradle minimizes head motion in awake fMRI at 15.2T without habituation

SangHan Choi1, Geun Ho Im1, Choong-Hee Lee1, and Seong-Gi Kim1,2
1Institute for Basic Science, Yuseong-gu, Korea, Republic of, 2Department of Biomedical Engineering, Sungkyunkwan University, Yuseong-gu, Korea, Republic of

Synopsis

Keywords: Task/Intervention Based fMRI, Animals, awake mouse fMRI

Motivation: Conducting awake-state fMRI experiments in mice is ideal. However, controlling head motions in awake mouse is challenging.

Goal(s): To develop and validate a head-motion-minimizing cradle setup for awake mouse fMRI without need for habituation training.

Approach: Visual stimulation fMRI was conducted on both awake and anesthetized mice at 15.2T using a newly designed cradle, which fixed head at three points while allowing free movement of the paws.

Results: The head motion was effectively controlled, and the BOLD response in the awake mouse visual fMRI dataset was found to be reliable.

Impact: We have developed and validated a head-motion-minimized cradle setup that enables awake mouse fMRI without pre-training. The proposed cradle setup reduces the effort required to minimize head motion for conducting awake mouse fMRI experiments.

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