Keywords: Task/Intervention Based fMRI, Animals, awake mouse fMRI
Motivation: Conducting awake-state fMRI experiments in mice is ideal. However, controlling head motions in awake mouse is challenging.
Goal(s): To develop and validate a head-motion-minimizing cradle setup for awake mouse fMRI without need for habituation training.
Approach: Visual stimulation fMRI was conducted on both awake and anesthetized mice at 15.2T using a newly designed cradle, which fixed head at three points while allowing free movement of the paws.
Results: The head motion was effectively controlled, and the BOLD response in the awake mouse visual fMRI dataset was found to be reliable.
Impact: We have developed and validated a head-motion-minimized cradle setup that enables awake mouse fMRI without pre-training. The proposed cradle setup reduces the effort required to minimize head motion for conducting awake mouse fMRI experiments.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords