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Abstract #5203

Quantitative synthetic MRI and 3D T1 imaging reveal structural and functional changes in hippocampal subfields in Type 2 Diabetes

Hailing Zhou1, Mingrui Li2, and Weiyin Vivian Liu3
1Department of Radiology, Central People's Hospital of Zhanjiang, Zhanjiang, China, 2Department of Radiology, Zhanjiang First Hospital of Traditional Chinese Medicine, Zhanjiang, China, 3MR Research, GE Healthcare, Beijing, China

Synopsis

Keywords: Synthetic MR, biomarkers

Motivation: T2DM accelerates hippocampal degeneration, raising cognitive decline risks. Clinically, identifying changes could early intervene to mitigate dementia risks in T2DM patients.

Goal(s): This study aims to uncover how T2DM leads to cognitive decline by examining MRI-derived changes in hippocampal subfields.

Approach: Of forty-two T2DM patients and fifty-one healthy controls, 3D T1 images and synthetic MRI was respectively used to assess volume and corresponding relaxation values across key hippocampal subfields (CA1, CA3, DG, subiculum).

Results: In T2DM patients showed reduced volumes in specific hippocampal regions and increased T1/T2 values, correlating with higher HbA1C(%) levels and cognitive impairment, emphasizing chronic hyperglycemia's impact on brain health.

Impact: This study demonstrates synthetic MRI’s utility in monitoring hippocampal subfields changes and cognitive decline in T2DM, providing insights into metabolic and neurovascular disruptions relevant to Alzheimer’s disease risk.

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