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Abstract #5215

Test-retest reliability and inter-method reproducibility of cerebral T1 mapping at 3T

Sarah Wright1, Vivian Truong1, Hasan Sawan1, Jiaqi Zhong1, and Yongsheng Chen1
1Neurology, Wayne State University School of Medicine, Detroit, MI, United States

Synopsis

Keywords: Quantitative Imaging, Validation

Motivation: Investigating the repeatability and reproducibility of human brain T1 mapping in vivo is required for transitioning clinical studies to a newly implemented MRI model.

Goal(s): This study aims to conduct a repeatability test for agreement of T1 values across test-retest scans. Additionally, it compares T1 reproducibility across three methods: STAGE, VFA-B1, and MR Fingerprinting.

Approach: Regional cerebral T1 values were measured in healthy volunteers with test-retest visits on the newly installed 3T MRI (Siemens Cima.X).

Results: Bland-Altman plots indicate that the mean test-retest differences for both 3D T1 mapping methods are close to zero, demonstrating a good test-retest repeatability.

Impact: This study demonstrated an excellent test-retest agreement of the two 3D T1 mapping methods on the newly implemented 3T MRI, which lays a cornerstone for future clinical studies in Parkinson's disease and multiple sclerosis using this scanner.

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Keywords