Keywords: Machine Learning/Artificial Intelligence, Neuro
Motivation: While T2* weighted imaging evaluates microbleeds, high-resolution 3D SWI requires long acquisition times with motion artifact risks. Fast imaging is needed for monitoring ARIA-H in Alzheimer's treatment.
Goal(s): To evaluate the diagnostic performance of DL Speed (DLS), a vendor-supplied prototype version of Sonic DL, which enables high acceleration rates and short scan times, in detecting microbleeds using DLS-reconstructed 3D SWAN.
Approach: 71 cognitive decline patients underwent T2*WI and 2mm DLS-SWAN. Two neuroradiologists conducted readings with and without DLS-SWAN.
Results: 2mm DLS-SWAN achieved whole-brain imaging with high resolution in less than 2 minutes, resulting in detection of significantly more definite microbleeds than T2*WI.
Impact: DLS-SWAN can potentially be useful as a rapid 3D T2* technique for screening MRI at baseline in patients undergoing monoclonal antibody therapy for Alzheimer disease.
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