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Abstract #5232

Differences in metabolic behavior of liver metastases of colorectal carcinoma: [18F]FDG-PET vs. DMI at 7T.

Li Shen Ho1,2, Arthur JAT Braat1,3, Maaike M Konig1,2, Mark Gosselink1,2, Dennis WJ Klomp1,2, Marnix GEH Lam1, and Jeanine J Prompers1,2,4
1Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, Netherlands, 2High Field MR Research Group, Center for Image Sciences, University Medical Centre Utrecht, Utrecht, Netherlands, 3Nuclear Medicine, Netherlands Cancer Institute, Amsterdam, Netherlands, 4Human Biology and Imaging, Maastricht University Medical Center+, Maastricht, Netherlands

Synopsis

Keywords: Deuterium, Cancer, Glucose metabolism, Liver metastases, Metabolic Imaging, Ultra high-field MRI, Non-proton

Motivation: [18F]FDG-PET scans of liver metastases of colorectal cancer (LMCRC) show varied metabolic profiles, but are often obscured by physiological liver glucose uptake. Measurement of tumor-specific glucose metabolism by deuterium metabolic imaging (DMI) could improve disease assessment.

Goal(s): To explore abberant glucose metabolism in LMCRC by both DMI and [18F]FDG-PET, providing initial insight into their potential complementarity.

Approach: Three patients with LMCRC were scanned using [18F]FDG-PET-CT and DMI at 7T.

Results: 2H-lactate signals were detected in areas corresponding to increased [18F]FDG-uptake, while no 2H-lactate signal was observed in necrotic tissue. At the same time, 2H-glucose signals were decreased in both active and necrotic lesions.

Impact: This study demonstrates that deuterium metabolic imaging can reveal distinct metabolic features in liver metastases of colorectal cancer, complementing [18F]FDG-PET by distinguishing necrotic and active tumor tissue, and thus providing a promising non-invasive tool for metabolic assessment in liver metastases.

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