Keywords: Deuterium, Cancer, Glucose metabolism, Liver metastases, Metabolic Imaging, Ultra high-field MRI, Non-proton
Motivation: [18F]FDG-PET scans of liver metastases of colorectal cancer (LMCRC) show varied metabolic profiles, but are often obscured by physiological liver glucose uptake. Measurement of tumor-specific glucose metabolism by deuterium metabolic imaging (DMI) could improve disease assessment.
Goal(s): To explore abberant glucose metabolism in LMCRC by both DMI and [18F]FDG-PET, providing initial insight into their potential complementarity.
Approach: Three patients with LMCRC were scanned using [18F]FDG-PET-CT and DMI at 7T.
Results: 2H-lactate signals were detected in areas corresponding to increased [18F]FDG-uptake, while no 2H-lactate signal was observed in necrotic tissue. At the same time, 2H-glucose signals were decreased in both active and necrotic lesions.
Impact: This study demonstrates that deuterium metabolic imaging can reveal distinct metabolic features in liver metastases of colorectal cancer, complementing [18F]FDG-PET by distinguishing necrotic and active tumor tissue, and thus providing a promising non-invasive tool for metabolic assessment in liver metastases.
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