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Abstract #5245

Optimization of a mixed block and event-related fMRS acquisition protocol for a working-memory task at 7T

Daniel Cocking1,2, Ryan Elson3, Katherine Dyke3, Mohammad Zia Ul Haq Katshu4,5, Claudia Danielmeier3, and Adam Berrington2
1School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3School of Psychology, University of Nottingham, Nottingham, United Kingdom, 4School of Medicine, University of Nottingham, Nottingham, United Kingdom, 5Nottinghamshire Healthcare NHS Foundation Trust, Nottingham, United Kingdom

Synopsis

Keywords: Spectroscopy, Spectroscopy

Motivation: The temporal response of metabolites during cognitive tasks is not well understood.

Goal(s): Optimize the timings and acquisition of an fMRS protocol at 7T within a working memory (WM) paradigm to allow for block and event analyses.

Approach: Compare glutamate (Glu) and GABA detection semi-LASER localisation at TE=30 ms and TE=80 ms across five volunteers to inform timings when designing a mixed ‘block and event-related’ protocol. Perform preliminary analysis of Glu concentrations using this approach.

Results: TE=80 ms improved GABA detection and led to reliable Glu detection with averages ≥4. Glu differences were observed across four subjects when comparing control vs. rest trials.

Impact: This study validates that TE=80ms semi-LASER improves GABA and Glu detection and offers a mixed-design fMRS protocol for cognitive studies. This opens the possibility to study temporal dynamics of glutamate during a working memory task.

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Keywords