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Abstract #5247

In Vivo Detection of Glutamate, Glutamine, and Glutathione at 3 T via Difference Editing of Aspartyl Resonances

Li An1, Sungtak Hong1, Tara Turon1, Adriana Pavletic1, Christopher Johnson1, and Jun Shen1
1National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States

Synopsis

Keywords: Spectroscopy, glutamine, glutathione, glutamate

Motivation: Glutamate and NAA-CH2 signals interfere with the detection of glutamine and glutathione at 3 T.

Goal(s): To enhance glutamine and glutathione detection by reliably quantifying NAA-CH2 and improving the resolution of glutamate and glutamine.

Approach: A novel NAA-CH2 difference editing technique was introduced for accurate spectral isolation of NAA-CH2 and optimal spectral resolution of glutamate and glutamine.

Results: NAA-CH2, glutamine, and glutathione were successfully resolved at 3 T. 13C turnover of spectrally resolved glutamate following oral administration of [U-13C]glucose was detected using spatially localized proton MRS at 3 T.

Impact: Time-course spectra following oral administration of [U-13C]glucose demonstrate, for the first time, the feasibility of measuring 13C turnover of spectrally resolved glutamate at 3 T with the high sensitivity and spatial resolution of proton MRS.

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