Abstract #5251

Longitudinal changes in epicardial adipose tissue volume in patients with heart failure following a 6-week weight-loss diet intervention

Neeraja Mahalingam^1,2, Christopher D. Crabtree^3,4, Katherine M. Binzel^2,5, Alyssa Marie M. Castillo^2,5, Jeff S. Volek⁴, Yuchi Han^2,5, and Orlando P. Simonetti^2,3,5

¹Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, ²Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ³Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ⁴Department of Human Sciences, The Ohio State University, Columbus, OH, United States, ⁵College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States

Synopsis

Keywords: Heart Failure, Cardiovascular, epicardial adipose tissue, repeatability

Motivation: Elevated epicardial adipose tissue (EAT) is associated with cardiovascular disease. Weight-loss diet interventions may aid in EAT reduction. Accurate determination of significant longitudinal changes requires knowledge of scan-scan repeatability.

Goal(s): In this work, scan-scan repeatability of EAT volume from cardiac MRI was evaluated in young, healthy individuals. Then, EAT changes over a 6-week-period were assessed in patients with heart failure following a weight-loss diet.

Approach: Healthy subjects underwent imaging twice within the same session; patients were imaged at baseline and 6 weeks.

Results: The repeatability coefficient for EAT volume was 18%. Seven out of ten patients demonstrated changes above this threshold.

Impact: Significant EAT volume changes greater than the repeatability coefficient were observed in patients with heart failure following a 6-week weight-loss diet. Cardiac MRI is sensitive in detecting changes in EAT volume that accompany weight loss induced by diet intervention.

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