Meeting Banner
Abstract #5261

Dynamic Pulmonary Vessel Analysis in Free-Breathing MRI using 2D-U-Net Segmentation

Julian Glandorf1,2, Marius M. Wernz1,2, Filip Klimeš1,2, Andreas Voskrebenzev1,2, Marcel Gutberlet1,2, Frank Wacker1,2, and Jens Vogel-Claussen1,2
1Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in End-stage and Obstructive Lung Disease Hannover (BREATH), Member of the German Centre for Lung Research (DZL), Hannover, Germany

Synopsis

Keywords: Vascular/Vessel Wall, Lung, Pulmonary Vasculature, Proton MRI, Pulmonary Hypertension, COPD, 2D-U-Net Segmentation

Motivation: Chronic lung diseases like chronic obstructive pulmonary disease and pulmonary hypertension remodel the pulmonary vasculature, affecting lung function and right heart performance.

Goal(s): This study aimed to analyze the central pulmonary vasculature using automated 2D-U-Net segmentation in free-breathing lung MRI, assessing reproducibility and disease-related differences.

Approach: Data from healthy participants, COPD-, and PH-patients were used to calculate dynamic vessel parameters, including vessel voxel counts, expansion between systole and diastole and phase shifts using 2D U-Net segmentation.

Results: Significant differences were observed in vessel size variability and phase shift between groups, highlighting potential non-invasive markers for distinguishing lung diseases.

Impact: This study demonstrates the potential of automated MRI-based vessel analysis to identify distinct hemodynamic changes in chronic lung diseases like COPD and PH. It could offer a non-invasive method to differentiate disease subtypes and monitor treatment responses in clinical practice.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords