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Abstract #5265

Left ventricular remodeling index predicts ventricular tachyarrhythmia in dilated cardiomyopathy with ejection fraction <35%

Xi Jia1, Xiuyu Chen1, and Shihua Zhao1
1Department of Magnetic Resonance Imaging, Fuwai Hospital, National Center for Cardiovascular Diseases of China, Chinese Academy of Medical Sci, Beijing, China

Synopsis

Keywords: Myocardium, Cardiomyopathy

Motivation: To identify who may benefit from implantable cardioverter-defibrillator (ICD) in end-stage dilated cardiomyopathy (DCM).

Goal(s): To explore the predictive value of a newly cardiac magnetic resonance (CMR) geometry parameter, LV remodeling index (LVRI), for ventricular tachyarrhythmia (VTA) in DCM patients with LVEF <35%.

Approach: Consecutive DCM patients with LVEF <35% (n=271) were followed up for VTA, including sudden cardiac death or major ventricular arrhythmias. Competing risk regression analysis was used to evaluate the association of LVRI with VTA.

Results: LVRI ≥7.5 is independently associated with lethal VTA in DCM patients with LVEF <35%.

Impact: CMR-derived LVRI is associated with VTA in patients with nonischemic DCM with LVEF <35%, which may have clinical significance in guiding future implantable cardioverter-defibrillator implantation and improving risk stratification for DCM patients with LVEF <35%.

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