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Abstract #5271

Quantitative Assessment of Post-Valvular Mechanical Energy in BAV with Aortic Lesions and Preserved Ejection Fraction on LV Workload

Shirin Aliabadi1 and Julio Garcia 2
1Biomedical Engineering, University of Calgary, Calgary, AB, Canada, 2Departments of Cardiac Sciences & Radiology, University of Calgary, Calgary, AB, Canada

Synopsis

Keywords: Flow, Flow, 4D flow cardiac MRI, Quantitative Imaging, Bicuspid aortic valve, left ventricular remodeling

Motivation: Bicuspid aortic valve (BAV) lesions, such as stenosis and regurgitation, increase the energetic load on the left ventricle (LV). Understanding how post-valvular mechanical energy relates to LV workload may aid in assessing cardiac risks.

Goal(s): Determine if post-valvular kinetic energy (KE) and viscous energy loss (EL) can quantify LV load associated with BAV lesions.

Approach: Four-dimensional cardiovascular magnetic resonance flow imaging data employed to calculate KE and EL in BAVs with different isolated lesion types.

Results: Elevated KE was observed in both regurgitation and stenosis, with notable correlations to LV functional and structural metrics, underscoring KE’s potential as a predictor of LV workload.

Impact: This study demonstrates that post-valvular peak systolic integrated kinetic energy (KE) could serve as a non-invasive marker of LV workload, supporting early intervention strategies for improved risk stratification in diverse BAV patient profiles.

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