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Abstract #5276

Cardiac magnetic resonance and genetics in pediatric heart failure with non-ischemia: prognostic implications

Xuelian Gao1,2, Jianxiu Lian3, Hui Wang1, and Xu Lei1
1Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, 2Nanchong Central Hospital Nanchong Hospital of Beijing Anzhen Hospital Affiliated to Capital Medical University, Nanchong, China, 3Philips Healthcare, Beijing, China

Synopsis

Keywords: Heart Failure, Cardiovascular

Motivation: To study the effects of cardiac magnetic resonance (CMR) and genetics on the prognosis of pediatric heart failure (HF) with non-ischemia.

Goal(s): To show the relationship between late gadolinium enhancement (LGE) of CMR and phenotype of genes and to explore the prognostic implications of HF.

Approach: The patients were divided into No-LGE group, Subendocardial group and No-Subendocardial group. The Phi coefficient, univariable and multivariable cox proportional hazard models and Kaplan-Meier method were assessed.

Results: MYH7 was the gene with largest proportion in this study. Non-ischemic HF can with uncommon sub-endocardial LGE and some parameters on CMR showed poor prognosis.

Impact: The study demonstrated the common genetic abnormalities in paediatric heart failure with non-ischemia and also reveal some relationship between genetics and late gadolinium enhancement. Cardiac magnetic resonance could provide valuable predictive information for pediatric heart failure with non-ischemia.

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