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Abstract #5279

Psoas Muscle Volume Measurement as a Predictor of Clinical Risk in Fontan Circulation

Sukran Erdem1, Orhan Erdem2, Mohammad Tarique Hussain3, Qing Zou1, Abhay Divekar4, Ryan Butts4, and Gerald Franz Greil3
1University of Texas Southwestern, Irving, TX, United States, 2University of North Texas, Irving, TX, United States, 3Pediatric Cardiology, University of Texas Southwestern, Dallas, TX, United States, 4University of Texas Southwestern, Dallas, TX, United States

Synopsis

Keywords: Cardiovascular, Diagnosis/Prediction, Fontan, Congenital heart disease, sarcopenia

Motivation: Reduced muscle mass is linked to adverse outcomes in patients with Fontan physiology. Psoas muscle volume measurement may enable more precise muscle mass assessment.

Goal(s): To identify whether psoas muscle area or volume is a more accurate predictor of adverse outcomes in Fontan patients.

Approach: Psoas muscle volume and area indexes, measured with abdominal MRI using the UTE sequence, were compared using logistic regression between patients with Fontan-associated complications and those with stable clinical progress.

Results: In patients with Fontan circulation, psoas muscle volume measurements are strongly correlated with area measurements and might show a stronger association with adverse outcomes than area.

Impact: The psoas muscle volume is a reproducible and easily obtained measurement using abdominal MRI, showing a strong correlation with the psoas muscle area. The psoas muscle volume could better correlate with these outcomes than the psoas muscle area.

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