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Abstract #5288

Assessing muscle deterioration in Duchenne muscular dystrophy using qMRI and muscle strength testing: a 12-month longitudinal study

Yingkun Guo1, Huayan Xu1, Rong Xu1, Hang Fu1, and Yu Song1
1Department of Radiology, Department of Radiology, West China Second University Hospital, Sichuan University, Chengdu, China

Synopsis

Keywords: Rare Disease, Quantitative Imaging

Motivation: Research on the correlation between muscle strength testing and qMRI in DMD, and its effectiveness in tracking muscle degeneration, remains limited.

Goal(s): To assess muscle strength degeneration in DMD patients over 12 months and verify the effectiveness of qMRI and strength testing in monitoring disease progression.

Approach: Patients underwent MRI of the gluteal muscles to determine FF and T1, alongside muscle strength testing to evaluate hip flexion, abduction, and adduction.

Results: This study shows a significant correlation between qMRI and muscle strength testing, especially adductor FF. Baseline FF of flexors, adductors, and abductors significantly predicts muscle strength changes over the following 12 months.

Impact: Our study offers insights to help clinicians implement effective, personalized management for early-stage DMD.

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