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Abstract #5292

Development of an MRI Pipeline for Non-Invasive Brown Adipose Tissue (BAT) Assessment in Paediatric Patients: A Preliminary Study

Elizabeth Stamou1,2, Jothi Venkatesh1, Madeleine Reid2, Aliya Amin2, Alice L Mitchell 3, Aleck WE Jones3, Philippa Bridgen2, Maria Gregori1, Nyree Griffin1, Rui Santos1, Eirini Kyrana2, Melanie Nana2, Michela Cleri2, Caroline Ovadia2, Laura Barredo Santos2, Anil Dhawan4, Emer Fitzpatrick4, Louise Dillon2, Radhouene Neji2, and Catherine Williamson3
1Guy's and St Thomas's NHS Trust, London, United Kingdom, 2King's College London, London, United Kingdom, 3Imperial College London, London, United Kingdom, 4King's College Hospital NHS Foundation Trust, London, United Kingdom

Synopsis

Keywords: Body, Liver, PDFF, R2*, Metabolism, Dixon, MASLD

Motivation: Research indicates that metabolic-associated steatotic liver disease (MASLD) impacts brown adipose tissue (BAT) activity. Current gold-standard assessment of BAT uses ionising radiation.

Goal(s): To develop and evaluate an MRI pipeline for the non-invasive assessment of BAT function in paediatric patients with MASLD and healthy controls (HC).

Approach: Enrolling 14 HC and 9 MASLD patients, we utilised a 6-point Dixon technique for proton density fat fraction (FF) and R2* measurements.

Results: Significant differences in BAT characteristics before and after cold exposure were observed in HC. However, limitations such as a small patient sample size emphasise the need for further larger studies.

Impact: The proposed MRI pipeline enables non-invasive assessment of brown adipose tissue, enhancing understanding of its role in energy metabolism. This method has significant implications for evaluating metabolic conditions, potentially improving patient outcomes in metabolic diseases.

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Keywords