Keywords: Body, Liver, PDFF, R2*, Metabolism, Dixon, MASLD
Motivation: Research indicates that metabolic-associated steatotic liver disease (MASLD) impacts brown adipose tissue (BAT) activity. Current gold-standard assessment of BAT uses ionising radiation.
Goal(s): To develop and evaluate an MRI pipeline for the non-invasive assessment of BAT function in paediatric patients with MASLD and healthy controls (HC).
Approach: Enrolling 14 HC and 9 MASLD patients, we utilised a 6-point Dixon technique for proton density fat fraction (FF) and R2* measurements.
Results: Significant differences in BAT characteristics before and after cold exposure were observed in HC. However, limitations such as a small patient sample size emphasise the need for further larger studies.
Impact: The proposed MRI pipeline enables non-invasive assessment of brown adipose tissue, enhancing understanding of its role in energy metabolism. This method has significant implications for evaluating metabolic conditions, potentially improving patient outcomes in metabolic diseases.
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