Motivation: Detect a mild traumatic brain injury with a reliable diagnostic for staging disease state and the testing therapies for treating the malady inacute and long term phase.
Goal(s): ): Develop a MRI biomarker that can be repeated used on patients especially in the warfighter population which have more that 500,000 diagnosed mTBI over the past 30 year.
Approach: Use of diffusion MRI to determine the white matter microstructural state namely the axon diameter.
Results: MAGNUS SE-DWI high-B can detect changes in axon diameter and follow these changes in single subject over time.
Impact: : High B-value diffusion imaging (b > 30000 mm2/sec) can detect changes in mild TBI subjects that can be seen to progress through the recoveryprocess. The high-performance gradient system, MAGNUS, (200mT/m, 500T/m/s) scanning without peripheral nerve stimulation in the subject.
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