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Abstract #5318

Differences in amplitude of low-frequency fluctuation in patients with chronic schizophrenia treated with different antipsychotics

Xinyue Chen1 and Lian Liu1
1Affiliated Hospital of North Sichuan Medical College, Nanchong, China

Synopsis

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Motivation: Whether there is a difference in the effects of long-term risperidone monotherapy versus risperidone combined with clozapine on functional brain activity in patients with chronic schizophrenia is unclear.

Goal(s): To compare differences in ALFF between risperidone monotherapy and the combination of risperidone and clozapine in patients with chronic schizophrenia.

Approach: Differences in ALFF between the risperidone-treated group, the risperidone combined with clozapine-treated group, and the normal control group were compared by ANCOVA.

Results: ALFF was reduced in the right caudate nucleus in the combined treatment group compared to the risperidone-treated group.

Impact: Differences in functional brain activity in the right caudate nucleus of chronic schizophrenic patients treated with different antipsychotic drugs.

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