Abstract #5352

Impact of denoising levels in compressed sensing accelerated MR Elastography on liver stiffness measurement in clinical patients

Scott G Hipko¹, Gretchen White¹, Naiim Ali^1,2, Dmitriy Akselrod^1,2, and Jiming Zhang^1,3

¹Radiology at Larner College of Medicine, University of Vermont, Burlinton, VT, United States, ²Radiology, University of Vermont Medical Center, Burlington, VT, United States, ³Medical Physics and Radiation Oncology, University of Vermont Medical Center, Burlington, VT, United States

Synopsis

Motivation: We previously studied compressed sensing(CS) to accelerate standard MRE(sMRE) and evaluated its accuracy on liver fibrosis staging. However, impact of denoising level used in CS on the quantitative method like MRE is unknown

Goal(s): To study the impact of different denoising levels in CS on the LS measurement

Approach: Quantify LS from three common denoising levels in csMRE and compared it to sMRE in a large cohort of clinical subjects.

Results: LS from all three denoising levels have similar accuracy but underestimated higher fibrosis stages. LS confident area with strong denoising increased 34% compared to sMRE.

Impact: csMRE shorten breath-hold duration significantly but underestimate the stiffness at higher fibrosis stages. A calibration curve is needed for csMRE to improve accuracy of fibrosis staging. The medium denoising level have a good balance between confident area and LS accuracy.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.