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Abstract #5354

Optimising Ex-Vivo Hand Imaging at Ultra-High FIeld (7T)

Tudor V. Sava1, Rebecca K. Glarin1, Casper G. Thorpe Lowis2, Bradford A. Moffat1, Ashish Singh1,2, Jennifer L. Wilkinson-Berka2,3, and Leigh A. Johnston1,4
1Melbourne Brain Centre Imaging Unit, University of Melbourne, Melbourne, Australia, 2Melbourne Academy of Surgical Anatomy, University of Melbourne, Melbourne, Australia, 3Department of Anatomy & Physiology, School of Biomedical Sciences, University of Melbourne, Melbourne, Australia, 4Biomedical Engineering & Graeme Clark Institute, University of Melbourne, Melbourne, Australia

Synopsis

Keywords:

Motivation: Ex-vivo MRI of hand specimens at ultra high field enables unprecedented, non-destructive, high resolution imaging not possible in-vivo. However, it poses a challenge requiring robust methodology and optimisation of vendor sequences that have not previously been reported.

Goal(s): Our goal was to determine preparation and acquisition methods for optimised spatial resolution and contrast.

Approach: Systematic testing of parameters for PD SPACE was conducted and evaluated with SNR and CNR calculations. Combinations of coils and specimen preparation methods were trialled.

Results: We demonstrate optimised methodology and sequence parameter choices enabling high-resolution imaging with superior contrast in ex-vivo hand tissue.

Impact: This work provides preparation methods and sequence parameters for imaging of ex-vivo hand specimens at UHF (7T) for high contrast and spatial resolution. This enables improved visualisation of anatomical detail and may be translated to other anatomical regions.

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Keywords