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Abstract #5372

Unveiling Brain Volume Patterns by Sex and Age in Marmosets

Kazumi Sogabe1, Junichi Hata2,3,4, Daisuke Yoshimaru3, Hinako Oshiro2, miyu okazaki2, Hideyuki Okano4,5, and Hirotaka James Okano3
1Teikyo University, TOKYO, Japan, 2TOKYO Metropolitan University, Tokyo, Japan, 3The Jikei University School of Medicine, Tokyo, Japan, 4Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Tokyo, Japan, 5Department of Physiology, Keio University School of Medicine, Tokyo, Japan

Synopsis

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Motivation: Sex-related differences in human brain volume have been documented in previous studies, with evidence suggesting a potential association with neurodegenerative diseases, particularly in specific brain regions.

Goal(s): The aim of this study is to investigate sex-related differences in the brain volume of marmosets, a nonhuman primate model commonly used in biomedical research, using MRI.

Approach: We conducted MRI scans on 445 healthy marmosets to measure total brain volume and the volume of specific brain regions.

Results: Across all age groups, females had notably smaller brain volumes than the males. The most pronounced differences were observed between the ages of 0.6 and 0.9 years.

Impact: This study highlights sex-related differences in marmoset brain volumes. These findings provide valuable insights into sex-specific brain development and contribute to our understanding of human neuroanatomy and pathogenesis of neurodegenerative diseases.

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