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Abstract #5381

Characteristics of white matter analysis with different constrained spherical deconvolution in patients with metastatic brain tumors and edema

Yuichi Suzuki1, Toshihiro Hayashi1, and Osamu Abe1
1Radiology center, The University of Tokyo Hospital, Tokyo, Japan

Synopsis

Motivation: This study compares three constrained spherical deconvolution (CSD) methods (SSST, MSMT, SS3T) for analyzing white matter fiber orientation in patients with metastatic brain tumors and edema.

Goal(s): To clarify the characteristics of each CSD analysis within normal white matter and edema.

Approach: We compared the macroscopic tissue type maps, apparent fibre density (AFD) and tractography.

Results: SS3T-CSD obtained results closer to the ODF of MSMT-CSD than SSST-CSD. AFD showed a tendency for MSMT-CSD to be higher in the white-gray matter boundary region. SS3T-CSD tended to show higher values than MSMT-CSD in edema regions. In tractography, SS3T-CSD showed superior visualization ability in the edema.

Impact: SS3T-CSD method, which uses single-shell diffusion-weighted data analysis, has a lower ability to depict the white matter-gray matter boundary area than MSMT-CSD method, which uses multi-shell diffusion-weighted data analysis, but may have better white matter visualization capabilities in edema.

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Keywords