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Abstract #5398

Semi-quantitative Evaluation of Myocardial Viability in Manganese-Enhanced MRI: A Rat Heart Transplant Model Study

Yuka Matsuura1, Koji Kawago2, Hiroyuki Takashima1,3, Gentaro Ikeda1, Yujiro Kawai2, Yasuhiro Shudo2, and Phillip C. Yang1
1Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, United States, 2Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States, 3Division of Biomedical engineering, Hokkaido University, Sapporo, Japan

Synopsis

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Motivation: Manganese enhanced MRI has shown promise in differentiating viable from non-viable myocardium, yet its potential for assessing the level of myocardial viability is unexplored.

Goal(s): To evaluate whether MEMRI can detect viability differences in rat heart transplant models through dynamic imaging of manganese uptake.

Approach: Rat hearts were transplanted either immediately or after 18-hour preservation. MEMRI was performed at three phases post-injection to calculate signal intensity ratios (SIR) in myocardial tissue, comparing changes over time between groups.

Results: SIR analysis revealed significant viability-dependent enhancement differences, particularly in late-phase imaging, supporting MEMRI’s role in early myocardial viability assessment for transplantation.

Impact: This study demonstrates that an increase in signal intensity ratio reflects the level of myocardial viability and highlights MEMRI’s potential for assessing myocardial viability in transplant models. This semi-quantitative approach could enhance clinical evaluations of myocardial viability.

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