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Abstract #5407

Ultra-High Contrast (UHC) MRI with bipolar filters: Obvious abnormalities in normal appearing brain, spinal cord and optic nerve

Paul Condron1,2, Daniel Cornfeld1,2, Mark Bydder1, Taylor Emsden1, Gil Newburn1, Joshua P McGeown1,2, and Graeme Bydder1,3
1Mātai Medical Research Institute, Gisborne, New Zealand, 2University of Auckland, Auckland, New Zealand, 3University of California, San Diego, San Diego, CA, United States

Synopsis

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Motivation: Many standard MRI brain scans fail to depict abnormalities in patients despite obvious findings in their clinical presentation. This can lead to negative health and social consequences.

Goal(s): Using ultra-high contrast (UHC) MRI we aimed to improve detection of subtle pathological changes that are invisible using standard MRI sequences.

Approach: 3D and 2D narrow and wide middle domain (mD) UHC images were acquired and compared with positionally matched conventional images.

Results: UHC MRI showed changes in disease that were inconspicuous on standard MRI images. Recovery of extensive white matter changes was seen and aligned with patient’s clinical status.

Impact: Standard MRI often fails to depict abnormalities despite changes in patient cognition, personality and/or physical state. Abnormalities can be seen in this situation with UHC MRI in otherwise normal-appearing brain, orbits and spinal cord, allowing improved diagnosis and management.

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