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Abstract #5420

Potential use of iTB Maps to Distinguish GBM Recurrence from Pseudoprogression Based on Performance in the Context of Tumor Infiltration

Robert Wujek1, Melissa Prah1, Mona Al-Gizawiy1, and Kathleen Schmainda1
1Biophysics, The Medical College of Wisconsin, Milwaukee, WI, United States

Synopsis

Motivation: The motivation for this study is to address the unmet need to distinguish glioblastoma recurrence from pseudoprogression (9009)

Goal(s): The goal is to assess the utility of a machine learning approach for distinguishing tumor infiltration from peritumoral edema in the context of solution features outlined in the 2025 challenge.

Approach: Multiparametric MRI (mpMRI) and biopsies from glioma were used as inputs to the infiltrative tumor burden (iTB) model to predict the presence of tumor within non-contrast enhancing, FLAIR enhancing regions, and subsequent iTB maps were generated.

Results: Performance and repeatability metrics validate this as a potentially useful approach for the unmet need.

Impact: The validation of iTB maps the context of tumor infiltration and in terms of the unmet need required features indicate that a similar approach may be utilized to distinguish glioblastoma recurrence from pseudoprogression.

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