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Abstract #5423

Fetal MR Thermometry Using Diffusion MRI.

Nahla M H Elsaid1, Kushal Kapse1, Nickie Andescavage1,2, and Catherine Limperopoulos1
1Developing Brain Institute, Children's National Hospital, Washington, DC, United States, 2Division of Neonatology, Childrens National Hospital, Washington, DC, United States

Synopsis

Motivation: Fetal absolute temperature monitoring ensures safety and stability during fetal MR scans, assessing thermoregulation, and pathological conditions. Noninvasive methods are needed.

Goal(s): To develop a noninvasive method for computing fetal absolute temperature by leveraging mean diffusivity from fetal brain DTI and true diffusivity from IVIM-based calculations in the amniotic fluid.

Approach: Mean diffusivity estimates from cerebrospinal-fluid (CSF), and pure water diffusion in amniotic fluid were obtained. Absolute temperature maps were estimated using a biophysical model.

Results: The study confirms that diffusivity-based temperature estimates in fetal CSF and amniotic fluid align with physiological expectations in four fetuses across different gestational ages and acquisition settings.

Impact: We implemented a method to directly compute the average fetal temperature from the CSF and the amniotic fluid diffusivity to measure the absolute fetal temperature.

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