Richard Leigh1, Argye Elizabeth Hillis2,
Peter B. Barker3
1Neurology, Johns Hopkins Univeristy
School of Medicine, Towson, MD, United States; 2Neurology, Johns
Hopkins University School of Medicine, Baltimore, MD, United States; 3Radiology,
Johns Hopkins Univeristy School of Medicine, Baltimore, MD, United States
Detection
of permeability derangements in stroke patients may help guide therapy and
improve outcomes. PWI, which is
routinely performed in stroke imaging, can be used to assess permeability
derangements through accumulation of contrast into the brain parenchyma. However it is unclear how the recorded
signal can be quantified and normalized across patients. We analyzed nine stroke patients with
evidence of contrast leakage on PWI to see how differences in acquisition
parameters affected the recorded signal.
We found that the measurements were greatly affected not only by the
acquisition parameters but also the tissue type from which the signal was
recorded.