Comprehensive assessment of the regional microstructure of the preterm human brain cerebral cortex using DKI and DTI
Tina Jeon 1 , Austin Ouyang 1 , Virendra Mishra 1 , Alejandra Perez 1 , Lina Chalak 2 , Jonathan Chia 3 , Muraleedharan Sivarajan 2 , Nancy Rollins 4 , and Hao Huang 1
Advanced Imaging Research Center, UT
Southwestern Medical Center, Dallas, Texas, United
of Pediatrics, UT Southwestern Medical Center, Dallas,
Texas, United States,
Medical Systems, Dallas, Texas, United States,
of Radiology, Children's Medical Center at Dallas,
Dallas, Texas, United States
From the early 3rd trimester to around birth, the
cerebral cortex undergoes rapid microstructural changes.
Decreases of fractional anisotropy (FA) derived from DTI
in cerebral cortex during this developmental period have
been well documented in the literature. Mean kurtosis
(MK), derived from diffusion kurtosis imaging (DKI),
quantifies restricted water diffusion in the cerebral
cortex and offers complementary information on cortical
microstructural development. In this study, we aim to
gain more comprehensive insight into regional
microstructural changes of cerebral cortex by combining
DKI and conventional DTI of the preterm human brains.
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