It has previously been demonstrated that, by using 3-tissue constrained spherical deconvolution, separate compartments encompassing cerebrospinal fluid-like, white matter-like, and grey matter-like, signal fractions can be derived from diffusion MRI data. This study explores the reliability of these compartments in three test-retest cohorts with a variety of timescales and scanning parameters. Whole-brain average signal fractions show excellent reliability across all datasets, particularly in determining the CSF-like signal fraction. This suggests that variations in whole brain signal fraction measurements are likely to be attributable to experimental manipulation or pathology and not variation introduced by performing the analysis.
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