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Abstract #0196

Investigation of DWI to Evaluate Prostate Thermal and Cryo Lesions

Chen J, Butts Pauly K, Daniel B, Sommer G, Bouley D
Stanford University

Fast, accurate and repeatable lesion evaluation is desirable for MRI-guided prostate therapies. In this work we investigate the use of diffusion weighted imaging (DWI) to estimate the cell viability immediately after the treatments. Line scan diffusion imaging is performed on six canine prostates with MRI-guided high intensity ultrasound thermal therapy or cryoablation. Significant ADC value reduction is observed in the thermal/cryo lesions. The necrotic tissue has an ADC trace value of approximately 0.001 mm2/second. Evident correlation between DWI and histology result is presented.