Evaluation of Emphysema Severity and Progression in a Rabbit Model: A Comparison of Hyperpolarized He-3 and Xe-129 ADC with Morphometry
Tobias W, Altes T, Mitzner W, Brookeman J, Ruppert K, Mugler III J, Mata J, Cai J, Cates G, Wang J
University of Virginia
In this study, hyperpolarized helium-3 and xenon-129 Apparent Diffusion Coefficient values were measured multiple times in the lungs of rabbits with induced emphysema during 8 weeks following elastase administration. Histology and morphometry of the lungs were performed at the end of the 8-week period and correlated with the in-vivo ADC values.