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Abstract #1452

The effect of interleukin-1 on local brain temperature during focal cerebral ischemia in the rat: a 1H magnetic resonance spectroscopic imaging study

Parry-Jones A, Liimatainen T, Grohn O, Kauppinen R, Rothwell N
University of Manchester

The pyrogen and pro-inflammatory cytokine interleukin-1 (IL-1) may exacerbate experimental stroke in part by increasing ischemic brain temperature. Rats undergoing middle cerebral artery occlusion received IL-1 or vehicle and brain temperature maps were generated by 1H-magnetic resonance spectroscopic imaging. IL-1 increased infarct volumes but rectal temperature (Tr) did not vary significantly between groups. At occlusion, ischemic brain temperature relative to Tr was -0.60.6C for vehicle and -1.20.9C for IL-1. During reperfusion these differences were +0.60.9C for vehicle and -0.61.0C for IL-1. Thus, IL-1 reduces ischemic brain temperature which may be a consequence of increased depth of ischemia.