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Abstract #1486

Metabolic interactions between glutamatergic and dopaminergic neurotransmiter systems are mediated through D1, but not D2, dopamine receptors

Cerdn S, Rodrigues T, Moratalla R, Martin A, Sanchz P
Inst. Inv. Biomedicas ""Alberto Sols"

Dopaminergic neurotransmission is modulated by dopamine D1 and D2 receptors, which appear to play a fundamental role in a variety of physiopathological states, including Parkinsons disease and cocaine addiction. These disturbances involve also alterations in glutamatergic neurotransmission, suggesting that cross modulation may exist between both neurotransmitter systems. However, the mechanisms of the interaction between dopaminergic and glutamatergic neurotransmissions remain unknown. We explore here these interactions using transgenic knock-out mice deficient in the dopamine D1 and D2 receptors, evaluating by 13C-NMR the glutamine cycle and associated glutamatergic neurotransmission. Removal of D1 receptors, but not D2 receptors, stimulate glutamatergic neurotransmission.