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Abstract #1491

Quantitative MR Spectroscopic Evaluation of Radiation-Induced Brain Injury in a Rat Model

Robbins M, Atwood T, Zhu J
Wake Forest University School of Medicine, Wake Forest University School of Medicine

In vivo localized MRS offers a tool to non-invasively study the metabolic and neuro-chemical changes throughout radiation treatment, which could help determine bio-markers that are relevant to normal tissue injury. This could also lead to the development of an accurate noninvasive imaging procedure to detect the neuro-functional changes at early stages. The specific aim of the current study was to detect and determine, using MRS, the long term neuro-chemical changes in rat brain associated with exposure to a clinically relevant dose of irradiation.