High field MR imaging of pre-invasive pancreatic carcinoma in a transgenic mouse model
Knop R, Venkatasubramanian P, Wyrwicz A, Grippo P
Evanston Northwestern Healthcare
The EL-Kras transgenic mouse develops premalignant lesions of pancreatic cancer, known as PanINs and is therefore a model of early pancreatic cancer progression. We have imaged pancreas from EL-Kras and normal mice ex vivo at high field strength. Our results show that PanINs in EL-Kras mouse pancreas could be differentiated from normal pancreas based only on classical endogenous contrast without the use of external contrast agents.