Blood Flow Increase in 9L Brain Tumors in Response to Radiation Therapy and Chemotherapy as Detected by Arterial Spin Labeling MRI
Sun P, Salhotra A, Bhujwalla Z, Zhou J, Laterra J, Lal B, van Zijl P
Johns Hopkins University, KKI
The response to tumor therapies was assessed in a rat model of 9L gliosarcoma through changes in the MRI relaxation times, apparent diffusion coefficients, and blood flow, in which blood flow was quantified by a non-invasive arterial spin label technique. The preliminary results show that the sensitivity of these MRI measures in response of therapy depends on applied therapeutic method and tumor age. There is a persistent substantial increase in blood flow in the region of treated tumors for both radiotherapy and chemotherapy.