A Smart PARACEST MRI Contrast Agent for Nitric Oxide Detection
Liu G, Pagel M
Case Western Reserve University
We have developed a smart PARACEST MR agent that changes its PARACEST effect only after chemical modification by Nitric Oxide. The amine and amide of Yb-DOTA-ortho-Aminoanilide show a PARACEST effect, but reaction with Nitric Oxide converts these functional groups to a hydrazine that doesnt demonstrate a PARACEST effect. This PARACEST MR agent can also be used to measure pH. This example constitutes a fundamentally new technology platform for smart MR agents.