A smart PARACEST agent for detection of Transglutaminase activity
Rosenblum R, Pagel M
Case Western Reserve University
We have developed a smart PARACEST MR agent that is detectable only after chemical modification by a specific enzyme. Yb-DO3A-pentylamine shows no PARACEST effect, but Transglutaminase catalyzes the reaction of this agent with glutamine to form an amide, which shows a PARACEST effect. This example constitutes a fundamentally new technology platform for smart MR agents.