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Abstract #2326

Novel Application of MEMRI Detects Sensory Deficits from Olfactory System Injury in Newborn Rabbit after Antenatal Hypoxia-Ischemia

Tan S, Drobyshevsky A, Robinson A, Wyrwicz A, Ji X, Englof I, Derrick M
Evanston Northwestern Healthcare

Smell deficits elicited by the motor response are observed in our cerebral palsy model of antenatal hypoxia-ischemia in rabbits. Manganese Enhanced MRI was applied to quantitatively asses the difference in manganese uptake and transport by olfactory epithelium neurons between control and post-hypoxic rabbit kits and whether this difference is augmented by specific odors. Amyl acetate exposure resulted in increased augmentation of the signal in control group. There was a significant decrease in manganese uptake in olfactory epithelium and olfactory bulbs in P1 kits following fetal hypoxia.