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Abstract #2524

Decomposition characteristics of brain tissue investigated at two different temperatures by means of 1H-MRS

Scheurer E, Ith M, Boesch C, Kreis R, Thali M
University & Inselspital Berne

Synopsis: Decomposition of brain tissue at 20C and at 4C was investigated by single voxel 1H-MRS in a sheep model over a period of 18 and 85 days, respectively. The results revealed that several metabolites show similar decomposition characteristics at both temperatures, however on a different time scale. Reproducible and unequivocal time courses of individual metabolite concentration allow for an estimation of the postmortem interval at both temperatures.